For research use only. Not for therapeutic Use.
Proparacaine Hydrochloride is the hydrochloride salt form of proparacaine, a benzoic acid derivative with local anesthetic property. It is used as a topical ophthalmic anesthetic. Proparacaine hydrochloride stabilizes the neuronal membrane by binding to and inhibiting voltage-gated sodium channels, thereby inhibiting sodium ion influx required for the initiation and conduction of impulses within the neuronal cell, and resulting in a loss of sensation.
Catalog Number | A001051 |
CAS Number | 5875-06-9 |
Synonyms | 5875-06-9; Proparacaine Hcl; Proxymetacaine hydrochloride; Ophthain; 2-(Diethylamino)ethyl 3-Amino-4-propoxybenzoate Hydrochloride |
Molecular Formula | C16H27ClN2O3 |
Purity | ≥95% |
Target | Apoptosis |
Solubility | >14.9mg/mL in DMSO |
Storage | -20°C |
InChI | 1S/C16H26N2O3.ClH/c1-4-10-20-15-8-7-13(12-14(15)17)16(19)21-11-9-18(5-2)6-3;/h7-8,12H,4-6,9-11,17H2,1-3H3;1H |
InChIKey | BFUUJUGQJUTPAF-UHFFFAOYSA-N |
SMILES | CCCOC1=C(C=C(C=C1)C(=O)OCCN(CC)CC)N.Cl |
Reference | 1: Little WB, Jean GS, Sithole F, Little E, Jean KY. Degree of corneal 2: Joshi RS. Proparacaine hydrochloride topical drop and intracameral 0.5% 3: Joshi RS. A single drop of 0.5% proparacaine hydrochloride for uncomplicated 4: Kalf KL, Utter ME, Wotman KL. Evaluation of duration of corneal anesthesia <br> 6: Herring IP, Bobofchak MA, Landry MP, Ward DL. Duration of effect and effect of 7: Cydulka RK, Betzelos S. Seizures following the use of proparacaine <br> <br> 10: TANTON JH. FLUORESCEIN-PROPARACAINE HYDROCHLORIDE. COMBINATION DROPS FOR |