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5875-06-9-Proparacaine Hydrochloride Proparacaine Hydrochloride

Proparacaine Hydrochloride

For research use only. Not for therapeutic Use.

  • CAT Number: A001051
  • CAS Number: 5875-06-9
  • Molecular Formula: C16H27ClN2O3
  • Molecular Weight: 330.85
  • Purity: ≥95%
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Proparacaine Hydrochloride is the hydrochloride salt form of proparacaine, a benzoic acid derivative with local anesthetic property. It is used as a topical ophthalmic anesthetic. Proparacaine hydrochloride stabilizes the neuronal membrane by binding to and inhibiting voltage-gated sodium channels, thereby inhibiting sodium ion influx required for the initiation and conduction of impulses within the neuronal cell, and resulting in a loss of sensation.


Catalog Number A001051
CAS Number 5875-06-9
Synonyms

5875-06-9; Proparacaine Hcl; Proxymetacaine hydrochloride; Ophthain; 2-(Diethylamino)ethyl 3-Amino-4-propoxybenzoate Hydrochloride

Molecular Formula C16H27ClN2O3
Purity ≥95%
Target Sodium Channel
Solubility >14.9mg/mL in DMSO
Storage -20°C
InChI 1S/C16H26N2O3.ClH/c1-4-10-20-15-8-7-13(12-14(15)17)16(19)21-11-9-18(5-2)6-3;/h7-8,12H,4-6,9-11,17H2,1-3H3;1H
InChIKey BFUUJUGQJUTPAF-UHFFFAOYSA-N
SMILES CCCOC1=C(C=C(C=C1)C(=O)OCCN(CC)CC)N.Cl
Reference

1: Little WB, Jean GS, Sithole F, Little E, Jean KY. Degree of corneal
anaesthesia after topical application of 0.4% oxybuprocaine hydrochloride and
0.5% proparacaine hydrochloride ophthalmic solution in clinically normal cattle.
Aust Vet J. 2016 Jun;94(6):181-5. doi: 10.1111/avj.12443. PubMed PMID: 27237118.
<br>

2: Joshi RS. Proparacaine hydrochloride topical drop and intracameral 0.5%
lignocaine for phacotrabeculectomy in patients with primary open angle glaucoma.
Middle East Afr J Ophthalmol. 2014 Jul-Sep;21(3):210-5. doi:
10.4103/0974-9233.134669. PubMed PMID: 25100903; PubMed Central PMCID:
PMC4123271.
<br>

3: Joshi RS. A single drop of 0.5% proparacaine hydrochloride for uncomplicated
clear corneal phacoemulsification. Middle East Afr J Ophthalmol. 2013
Jul-Sep;20(3):221-4. doi: 10.4103/0974-9233.114795. PubMed PMID: 24014985; PubMed
Central PMCID: PMC3757631.
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4: Kalf KL, Utter ME, Wotman KL. Evaluation of duration of corneal anesthesia
induced with ophthalmic 0.5% proparacaine hydrochloride by use of a Cochet-Bonnet
aesthesiometer in clinically normal horses. Am J Vet Res. 2008 Dec;69(12):1655-8.
doi: 10.2460/ajvr.69.12.1655. PubMed PMID: 19046014.

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5: Binder DR, Herring IP. Duration of corneal anesthesia following topical
administration of 0.5% proparacaine hydrochloride solution in clinically normal
cats. Am J Vet Res. 2006 Oct;67(10):1780-2. PubMed PMID: 17014333.
<br>

6: Herring IP, Bobofchak MA, Landry MP, Ward DL. Duration of effect and effect of
multiple doses of topical ophthalmic 0.5% proparacaine hydrochloride in
clinically normal dogs. Am J Vet Res. 2005 Jan;66(1):77-80. PubMed PMID:
15691039.
<br>

7: Cydulka RK, Betzelos S. Seizures following the use of proparacaine
hydrochloride eye drops. J Emerg Med. 1990 Mar-Apr;8(2):131-3. PubMed PMID:
2362113.

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8: Brent MH, Slomovic AR, Easterbrook M. Keratitis associated with the use of
proparacaine hydrochloride. CMAJ. 1987 Feb 15;136(4):380-1. PubMed PMID: 3815202;
PubMed Central PMCID: PMC1492048.

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9: Ward B, McCulley JP, Segal RJ. Dermatologic reaction in Stevens-Johnson
syndrome after ophthalmic anesthesia with proparacaine hydrochloride. Am J
Ophthalmol. 1978 Jul;86(1):133-5. PubMed PMID: 354393.
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10: TANTON JH. FLUORESCEIN-PROPARACAINE HYDROCHLORIDE. COMBINATION DROPS FOR
APPLANATION TONOMETRY. Am J Ophthalmol. 1964 Dec;58:1055-6. PubMed PMID:
14233708.

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