Propargyl-C2-NHS ester

• CAT Number: I017612
• CAS Number: 906564-59-8
• Molecular Formula: C₁₀H₁₁NO₄
• Molecular Weight: 209.2
• Purity: ≥95%
• Target: ADC Linker
• IUPAC Name: (2,5-dioxopyrrolidin-1-yl) hex-5-ynoate
• InChI: InChI=1S/C10H11NO4/c1-2-3-4-5-10(14)15-11-8(12)6-7-9(11)13/h1H,3-7H2
• InChIKey: CXSSWEBEHUYETJ-UHFFFAOYSA-N
• SMILES: C#CCCCC(=O)ON1C(=O)CCC1=O

Propargyl-C2-NHS ester（Cat No.:I017612） is a noncleavable linker used in antibody-drug conjugation (ADC) strategies. It acts as a coupling agent to attach drugs or payloads to antibodies. The linker contains a propargyl group that allows for conjugation through bioorthogonal chemistry, specifically click chemistry. This linker forms a stable covalent bond between the drug and the antibody, resulting in a noncleavable ADC.