Propargyl-PEG1-acid

• CAT Number: I014592
• CAS Number: 55683-37-9
• Molecular Formula: C6H8O3
• Molecular Weight: 128.13
• Purity: ≥95%
• Synonyms: Propargyl-PEG1-acid;3-(2-Propynyloxy)propanoic acid
• Target: PROTAC Linkers
• Solubility: Soluble in DMSO
• InChI: InChI=1S/C6H8O3/c1-2-4-9-5-3-6(7)8/h1H,3-5H2,(H,7,8)
• InChIKey: GMFDYXLFHSFUHE-UHFFFAOYSA-N
• SMILES: O=C(O)CCOCC#C

Propargyl-PEG1-acid is a PEG derivative containing a propargyl group with a terminal carboxylic acid. The terminal carboxylic acid can reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond. The propargyl group can be reacted with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage.