For research use only. Not for therapeutic Use.
Propargyl-PEG1-NH2 is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. Propargyl-PEG1-NH2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
| Catalog Number | I014593 |
| CAS Number | 122116-12-5 |
| Synonyms | 2-prop-2-ynoxyethanamine |
| Molecular Formula | C5H9NO |
| Purity | ≥95% |
| InChI | InChI=1S/C5H9NO/c1-2-4-7-5-3-6/h1H,3-6H2 |
| InChIKey | MZFRRBQTCNHISM-UHFFFAOYSA-N |
| SMILES | C#CCOCCN |
| Reference | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. |
