Propargyl-PEG1-SS-PEG1-acid

• CAT Number: I016129
• CAS Number: 1807503-85-0
• Molecular Formula: C10H16O4S2
• Molecular Weight: 264.36
• Purity: ≥95%
• Synonyms: 3-[2-(2-prop-2-ynoxyethyldisulfanyl)ethoxy]propanoic acid
• InChI: InChI=1S/C10H16O4S2/c1-2-4-13-6-8-15-16-9-7-14-5-3-10(11)12/h1H,3-9H2,(H,11,12)
• InChIKey: OEMFYMUYWYWVRT-UHFFFAOYSA-N
• SMILES: C#CCOCCSSCCOCCC(=O)O

Propargyl-PEG1-SS-PEG1-acid is a cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Propargyl-PEG1-SS-PEG1-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

Reference

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.
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