Propargyl-PEG1-SS-PEG1-C2-Boc

• CAT Number: I016949
• CAS Number: 1807518-78-0
• Molecular Formula: C14H24O4S2
• Molecular Weight: 320.47
• Purity: ≥95%
• Synonyms: tert-butyl 3-[2-(2-prop-2-ynoxyethyldisulfanyl)ethoxy]propanoate
• InChI: InChI=1S/C14H24O4S2/c1-5-7-16-9-11-19-20-12-10-17-8-6-13(15)18-14(2,3)4/h1H,6-12H2,2-4H3
• InChIKey: HXQOZIFQBVKJGA-UHFFFAOYSA-N
• SMILES: CC(C)(C)OC(=O)CCOCCSSCCOCC#C

Propargyl-PEG1-SS-PEG1-C2-Boc is a Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG1-SS-PEG1-C2-Boc is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Propargyl-PEG1-SS-PEG1-C2-Boc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

Reference

[1]. Barrientos AG, et al. Gold glyconanoparticles: synthetic polyvalent ligands mimicking glycocalyx-like surfaces as tools for glycobiological studies. Chemistry. 2003 May 9;9(9):1909-21.
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