For research use only. Not for therapeutic Use.
Propargyl-PEG2-acid is a PEG derivative containing a propargyl group with a terminal carboxylic acid. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The propargyl group can be reacted with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage.
| Catalog Number | I014597 |
| CAS Number | 1859379-85-3 |
| Synonyms | Propargyl-PEG2-acid;3-(2-(prop-2-yn-1-yloxy)ethoxy)propanoic acid |
| Molecular Formula | C8H12O4 |
| Purity | ≥95% |
| Target | PROTAC |
| Solubility | Soluble in DMSO |
| InChI | InChI=1S/C8H12O4/c1-2-4-11-6-7-12-5-3-8(9)10/h1H,3-7H2,(H,9,10) |
| InChIKey | NNWHATPXNWOQKD-UHFFFAOYSA-N |
| SMILES | O=C(O[H])CCOCCOCC#C |
| Reference | </br>1: Sano K, Nakajima T, Miyazaki K, Ohuchi Y, Ikegami T, Choyke PL, Kobayashi H. Short PEG-linkers improve the performance of targeted, activatable monoclonal antibody-indocyanine green optical imaging probes. Bioconjug Chem. 2013 May 15;24(5):811-6. doi: 10.1021/bc400050k. Epub 2013 May 3. PubMed PMID: 23600922; PubMed Central PMCID: PMC3674550.</br></br> |
