Propargyl-PEG2-Boc

• CAT Number: I014601
• CAS Number: 1807503-80-5
• Molecular Formula: C12H20O4
• Molecular Weight: 228.28
• Purity: ≥95%
• Synonyms: tert-butyl 3-(2-prop-2-ynoxyethoxy)propanoate
• InChI: InChI=1S/C12H20O4/c1-5-7-14-9-10-15-8-6-11(13)16-12(2,3)4/h1H,6-10H2,2-4H3
• InChIKey: DPARWKDJMUCBKM-UHFFFAOYSA-N
• SMILES: CC(C)(C)OC(=O)CCOCCOCC#C

Propargyl-PEG2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG2-Boc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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