Propargyl-PEG2-MS

• CAT Number: I014606
• CAS Number: 943726-01-0
• Molecular Formula: C8H14O5S
• Molecular Weight: 222.26
• Purity: ≥95%
• Synonyms: 2-(2-prop-2-ynoxyethoxy)ethyl methanesulfonate
• InChI: InChI=1S/C8H14O5S/c1-3-4-11-5-6-12-7-8-13-14(2,9)10/h1H,4-8H2,2H3
• InChIKey: CNUSDGRUYDRKPO-UHFFFAOYSA-N
• SMILES: CS(=O)(=O)OCCOCCOCC#C

Propargyl-PEG2-MS is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. Propargyl-PEG2-MS is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Reference

[1]. Bai S, et al. Synthesis and structure-activity relationship studies of conformationally flexibletetrahydroisoquinolinyl triazole carboxamide and triazole substituted benzamide analogues as σ2 receptor ligands. J Med Chem. 2014 May 22;57(10):4239-51.
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