Propargyl-PEG2-Tos

• CAT Number: I016008
• CAS Number: 145916-41-2
• Molecular Formula: C₁₂H₁₄O₄S
• Molecular Weight: 254.3
• Purity: ≥95%
• Target: PROTAC Linkers
• IUPAC Name: 2-prop-2-ynoxyethyl 4-methylbenzenesulfonate
• InChI: InChI=1S/C12H14O4S/c1-3-8-15-9-10-16-17(13,14)12-6-4-11(2)5-7-12/h1,4-7H,8-10H2,2H3
• InChIKey: KTEIFCKZGZZTHP-UHFFFAOYSA-N
• SMILES: CC1=CC=C(C=C1)S(=O)(=O)OCCOCC#C

Propargyl-PEG2-Tos（Cat No.:I016008） is a PEG-based PROTAC linker utilized in the synthesis of PROTACs (proteolysis-targeting chimeras). It consists of a PEG (polyethylene glycol) chain linked to a tosyl (tosylate) group through a propargyl linker. This linker allows for the conjugation of a target protein-binding ligand to a ligand that recruits an E3 ubiquitin ligase, facilitating targeted protein degradation. Propargyl-PEG2-Tos serves as a crucial component in the construction of PROTAC molecules, enabling the development of novel therapeutics for diseases associated with specific protein targets.

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562