For research use only. Not for therapeutic Use.
Propargyl-PEG24-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG24-amine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
| Catalog Number | I014596 |
| Synonyms | 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanamine |
| Molecular Formula | C51H101NO24 |
| Purity | ≥95% |
| InChI | InChI=1S/C51H101NO24/c1-2-4-53-6-8-55-10-12-57-14-16-59-18-20-61-22-24-63-26-28-65-30-32-67-34-36-69-38-40-71-42-44-73-46-48-75-50-51-76-49-47-74-45-43-72-41-39-70-37-35-68-33-31-66-29-27-64-25-23-62-21-19-60-17-15-58-13-11-56-9-7-54-5-3-52/h1H,3-52H2 |
| InChIKey | HGSYDCLOMGZXGT-UHFFFAOYSA-N |
| SMILES | C#CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN |
| Reference | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
