For research use only. Not for therapeutic Use.
Propargyl-PEG3-acid is a PEG derivative containing a propargyl group with a terminal carboxylic acid. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The propargyl group can be reacted with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage.
| Catalog Number | I014602 |
| CAS Number | 1347760-82-0 |
| Synonyms | Propargyl-PEG3-acid; Propyne-PEG2-CH2CH2COOH;3-(2-(2-(prop-2-yn-1-yloxy)ethoxy)ethoxy)propanoic acid |
| Molecular Formula | C10H16O5 |
| Purity | ≥95% |
| Target | PROTAC |
| Solubility | Soluble in DMSO |
| InChI | InChI=1S/C10H16O5/c1-2-4-13-6-8-15-9-7-14-5-3-10(11)12/h1H,3-9H2,(H,11,12) |
| InChIKey | CJNSWLAJTZVSRB-UHFFFAOYSA-N |
| SMILES | OC(CCOCCOCCOCC#C)=O |
| Reference | </br>1: Sano K, Nakajima T, Miyazaki K, Ohuchi Y, Ikegami T, Choyke PL, Kobayashi H. Short PEG-linkers improve the performance of targeted, activatable monoclonal antibody-indocyanine green optical imaging probes. Bioconjug Chem. 2013 May 15;24(5):811-6. doi: 10.1021/bc400050k. Epub 2013 May 3. PubMed PMID: 23600922; PubMed Central PMCID: PMC3674550.</br></br> |
