For research use only. Not for therapeutic Use.
Propargyl-PEG3-SH（Cat No.:I016321）is a chemical compound commonly used in bioconjugation and drug delivery applications. It consists of a propargyl group (an alkyne), a three-unit polyethylene glycol (PEG3) linker, and a thiol (SH) group. The propargyl group is reactive in click chemistry reactions, particularly with azides, enabling selective conjugation of biomolecules. The PEG3 spacer provides solubility, stability, and reduces nonspecific interactions, while the thiol group allows for the attachment of molecules via disulfide bonds or thiol-ene chemistry. This compound is often used in the development of targeted therapeutics, imaging agents, and biosensors.
| Catalog Number | I016321 |
| CAS Number | 1412905-18-0 |
| Molecular Formula | C₉H₁₆O₃S |
| Purity | ≥95% |
| Target | PROTAC Linkers |
| IUPAC Name | 2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethanethiol |
| InChI | InChI=1S/C9H16O3S/c1-2-3-10-4-5-11-6-7-12-8-9-13/h1,13H,3-9H2 |
| InChIKey | VHLQMMQFEBUDNF-UHFFFAOYSA-N |
| SMILES | C#CCOCCOCCOCCS |
| Reference | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
