For research use only. Not for therapeutic Use.
Propargyl-PEG4-bromide（Cat No.:I014612）is a chemical compound consisting of a propargyl group (an alkyne), a four-unit polyethylene glycol (PEG) chain, and a bromide (Br) functional group. The propargyl group allows for click chemistry reactions, enabling efficient conjugation with other molecules such as peptides, proteins, or drugs. The PEG4 chain enhances solubility, stability, and biocompatibility, while the bromide group provides a reactive site for further functionalization. Propargyl-PEG4-bromide is commonly used in drug delivery, molecular biology, and bioconjugation applications, particularly for creating targeted therapies, imaging agents, or bioactive compound libraries.
| Catalog Number | I014612 |
| CAS Number | 1308299-09-3 |
| Synonyms | Propargyl-PEG4-bromide;Propargyl-PEG4-bromide |
| Molecular Formula | C11H19BrO4 |
| Purity | ≥95% |
| Target | PROTAC |
| Solubility | Soluble in DMSO |
| IUPAC Name | 3-[2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]ethoxy]prop-1-yne |
| InChI | InChI=1S/C11H19BrO4/c1-2-4-13-6-8-15-10-11-16-9-7-14-5-3-12/h1H,3-11H2 |
| InChIKey | BITLDNUKJCDASJ-UHFFFAOYSA-N |
| SMILES | C#CCOCCOCCOCCOCCBr |
| Reference | </br>1: Sano K, Nakajima T, Miyazaki K, Ohuchi Y, Ikegami T, Choyke PL, Kobayashi H. Short PEG-linkers improve the performance of targeted, activatable monoclonal antibody-indocyanine green optical imaging probes. Bioconjug Chem. 2013 May 15;24(5):811-6. doi: 10.1021/bc400050k. Epub 2013 May 3. PubMed PMID: 23600922; PubMed Central PMCID: PMC3674550. </br>2: Harrison E, Coulter JA, Dixon D. Gold nanoparticle surface functionalization: mixed monolayer versus hetero bifunctional peg linker. Nanomedicine (Lond). 2016 Apr;11(7):851-65. Review. PubMed PMID: 27021417.</br>3: Augusto MT, Hollmann A, Porotto M, Moscona A, Santos NC. Antiviral Lipopeptide-Cell Membrane Interaction Is Influenced by PEG Linker Length. Molecules. 2017 Jul 15;22(7). pii: E1190. doi: 10.3390/molecules22071190. PubMed PMID: 28714870; PubMed Central PMCID: PMC5776016.</br>4: Tuma R, Russell M, Rosendahl M, Thomas GJ Jr. Solution conformation of the extracellular domain of the human tumor necrosis factor receptor probed by Raman and UV-resonance Raman spectroscopy: structural effects of an engineered PEG linker. Biochemistry. 1995 Nov 21;34(46):15150-6. PubMed PMID: 7578129. </br> </br> |
