For research use only. Not for therapeutic Use.
Propargyl-PEG4-CH2CO2H (Cat No.: I014615) is a functionalized polyethylene glycol (PEG) linker with a terminal propargyl (alkyne) and a carboxyl (-CO2H) group. The propargyl moiety enables click chemistry reactions, particularly copper-catalyzed azide-alkyne cycloaddition (CuAAC), allowing for efficient bioconjugation. The PEG4 spacer enhances solubility, flexibility, and minimizes steric hindrance in biomolecular interactions. This linker is widely used in drug delivery, peptide modification, and bioconjugation applications, providing a versatile tool for chemical biology and pharmaceutical research involving targeted molecule design and functionalization.
| CAS Number | 1694731-93-5 |
| Synonyms | Propargyl-PEG4-CH2CO2H;Propargyl-PEG4-CH2CO2H |
| Molecular Formula | C11H18O6 |
| Purity | ≥95% |
| Target | PROTAC Linkers |
| Solubility | Soluble in DMSO |
| InChI | InChI=1S/C11H18O6/c1-2-3-14-4-5-15-6-7-16-8-9-17-10-11(12)13/h1H,3-10H2,(H,12,13) |
| InChIKey | MJRNNISHHNMYAE-UHFFFAOYSA-N |
| SMILES | OC(COCCOCCOCCOCC#C)=O |
| Reference | </br>1: Sano K, Nakajima T, Miyazaki K, Ohuchi Y, Ikegami T, Choyke PL, Kobayashi H. Short PEG-linkers improve the performance of targeted, activatable monoclonal antibody-indocyanine green optical imaging probes. Bioconjug Chem. 2013 May 15;24(5):811-6. doi: 10.1021/bc400050k. Epub 2013 May 3. PubMed PMID: 23600922; PubMed Central PMCID: PMC3674550.</br></br> |
