For research use only. Not for therapeutic Use.
Propargyl-PEG4-CH2CO2H is a PEG derivative containing a propargyl group with a terminal carboxylic acid. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The propargyl group can be reacted with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage.
Catalog Number | I014615 |
CAS Number | 1694731-93-5 |
Synonyms | Propargyl-PEG4-CH2CO2H;Propargyl-PEG4-CH2CO2H |
Molecular Formula | C11H18O6 |
Purity | ≥95% |
Target | PROTAC Linkers |
Solubility | Soluble in DMSO |
InChI | InChI=1S/C11H18O6/c1-2-3-14-4-5-15-6-7-16-8-9-17-10-11(12)13/h1H,3-10H2,(H,12,13) |
InChIKey | MJRNNISHHNMYAE-UHFFFAOYSA-N |
SMILES | OC(COCCOCCOCCOCC#C)=O |
Reference | </br>1: Sano K, Nakajima T, Miyazaki K, Ohuchi Y, Ikegami T, Choyke PL, Kobayashi H. Short PEG-linkers improve the performance of targeted, activatable monoclonal antibody-indocyanine green optical imaging probes. Bioconjug Chem. 2013 May 15;24(5):811-6. doi: 10.1021/bc400050k. Epub 2013 May 3. PubMed PMID: 23600922; PubMed Central PMCID: PMC3674550.</br></br> |