Propargyl-PEG4-CH2CO2H

For research use only. Not for therapeutic Use.

  • CAT Number: I014615
  • CAS Number: 1694731-93-5
  • Molecular Formula: C11H18O6
  • Molecular Weight: 246.26
  • Purity: ≥95%
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Propargyl-PEG4-CH2CO2H is a PEG derivative containing a propargyl group with a terminal carboxylic acid. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The propargyl group can be reacted with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage.


Catalog Number I014615
CAS Number 1694731-93-5
Synonyms

Propargyl-PEG4-CH2CO2H;Propargyl-PEG4-CH2CO2H

Molecular Formula C11H18O6
Purity ≥95%
Target PROTAC Linkers
Solubility Soluble in DMSO
InChI InChI=1S/C11H18O6/c1-2-3-14-4-5-15-6-7-16-8-9-17-10-11(12)13/h1H,3-10H2,(H,12,13)
InChIKey MJRNNISHHNMYAE-UHFFFAOYSA-N
SMILES OC(COCCOCCOCCOCC#C)=O
Reference

</br>1: Sano K, Nakajima T, Miyazaki K, Ohuchi Y, Ikegami T, Choyke PL, Kobayashi H. Short PEG-linkers improve the performance of targeted, activatable monoclonal antibody-indocyanine green optical imaging probes. Bioconjug Chem. 2013 May 15;24(5):811-6. doi: 10.1021/bc400050k. Epub 2013 May 3. PubMed PMID: 23600922; PubMed Central PMCID: PMC3674550.</br></br>

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