Propargyl-PEG4-Maleimide

• CAT Number: I014618
• CAS Number: 1609651-90-2
• Molecular Formula: C18H26N2O7
• Molecular Weight: 382.41
• Purity: ≥95%
• Synonyms: Propargyl-PEG4-Maleimide;Propargyl-PEG4-Maleimide
• Target: PROTAC Linkers
• Solubility: Soluble in DMSO
• InChI: InChI=1S/C18H26N2O7/c1-2-8-24-10-12-26-14-15-27-13-11-25-9-6-19-16(21)5-7-20-17(22)3-4-18(20)23/h1,3-4H,5-15H2,(H,19,21)
• InChIKey: GHEBECZRHJXPTL-UHFFFAOYSA-N
• SMILES: O=C1N(CCC(NCCOCCOCCOCCOCC#C)=O)C(C=C1)=O

Propargyl-PEG4-Maleimide is a PEG derivative containing a propargyl group and a maleimide group. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. The terminal alkyne will react with azides via copper-catalyzed Click Chemistry. PEG Linkers are useful for the development of antibody drug conjugates.

Reference

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