For research use only. Not for therapeutic Use.
Propargyl-PEG4-NHS ester is a PEG derivative containing a propargyl group and an NHS ester group. The hydrophilic PEG spacer increases solubility in aqueous media. This reagent has a terminal NHS ester and is an amine reactive reagent for derivatizing peptides, antibodies, amine coated surfaces etc. The propargyl group can be reacted with azide-bearing compounds or biomolecules via copper catalyzed azide-NHS ester Click Chemistry to yield a stable triazole linkage.
| Catalog Number | I014621 |
| CAS Number | 1428629-70-2 |
| Synonyms | Propargyl-PEG4-NHS ester;Propargyl-PEG4-NHS ester |
| Molecular Formula | C16H23NO8 |
| Purity | ≥95% |
| Target | ADC Linker |
| Solubility | Soluble in DMSO |
| InChI | InChI=1S/C12H19O6.C4H4NO2/c1-2-4-15-6-8-17-10-11-18-9-7-16-5-3-12(13)14;6-3-1-2-4(7)5-3/h1H,3-11H2;1-2H2 |
| InChIKey | WMBISYJCYQJEQK-UHFFFAOYSA-N |
| SMILES | [O]C(CCOCCOCCOCCOCC#C)=O.O=C1[N]C(CC1)=O |
| Reference | </br>1: Sano K, Nakajima T, Miyazaki K, Ohuchi Y, Ikegami T, Choyke PL, Kobayashi H. Short PEG-linkers improve the performance of targeted, activatable monoclonal antibody-indocyanine green optical imaging probes. Bioconjug Chem. 2013 May 15;24(5):811-6. doi: 10.1021/bc400050k. Epub 2013 May 3. PubMed PMID: 23600922; PubMed Central PMCID: PMC3674550.</br></br> |
