Propargyl-PEG4-O-C1-Boc

• CAT Number: I014630
• CAS Number: 2098489-63-3
• Molecular Formula: C17H30O7
• Molecular Weight: 346.42
• Purity: ≥95%
• Synonyms: tert-butyl 2-[2-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]ethoxy]acetate
• InChI: InChI=1S/C17H30O7/c1-5-6-19-7-8-20-9-10-21-11-12-22-13-14-23-15-16(18)24-17(2,3)4/h1H,6-15H2,2-4H3
• InChIKey: ZYUYTWWDQAPZRS-UHFFFAOYSA-N
• SMILES: CC(C)(C)OC(=O)COCCOCCOCCOCCOCC#C

Propargyl-PEG4-O-C1-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. Propargyl-PEG4-O-C1-Boc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Reference

[1]. Wurz RP, et al. A “Click Chemistry Platform” for the Rapid Synthesis of Bispecific Molecules for Inducing ProteinDegradation. J Med Chem. 2018 Jan 25;61(2):453-461.
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