For research use only. Not for therapeutic Use.
Propargyl-PEG5-amine（Cat No.:I014626）is a versatile compound consisting of a propargyl group linked to a five-unit polyethylene glycol (PEG) chain, ending in an amine group. This structure makes it highly useful in chemical biology and drug delivery applications. The propargyl group allows for click chemistry reactions, enabling easy conjugation to other molecules, such as peptides or drugs. The PEGylation enhances solubility, stability, and biocompatibility, while the amine group facilitates further functionalization. Propargyl-PEG5-amine is used in the synthesis of bioactive molecules, targeted therapies, and in creating molecular probes for biological research.
| Catalog Number | I014626 |
| CAS Number | 1589522-46-2 |
| Synonyms | Propargyl-PEG5-amine;Propargyl-PEG5-amine |
| Molecular Formula | C13H25NO5 |
| Purity | ≥95% |
| Target | PROTAC |
| Solubility | Soluble in DMSO |
| IUPAC Name | 2-[2-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]ethoxy]ethanamine |
| InChI | InChI=1S/C13H25NO5/c1-2-4-15-6-8-17-10-12-19-13-11-18-9-7-16-5-3-14/h1H,3-14H2 |
| InChIKey | BLBTXXAWMPTQOK-UHFFFAOYSA-N |
| SMILES | C#CCOCCOCCOCCOCCOCCN |
| Reference | </br>1: Sano K, Nakajima T, Miyazaki K, Ohuchi Y, Ikegami T, Choyke PL, Kobayashi H. Short PEG-linkers improve the performance of targeted, activatable monoclonal antibody-indocyanine green optical imaging probes. Bioconjug Chem. 2013 May 15;24(5):811-6. doi: 10.1021/bc400050k. Epub 2013 May 3. PubMed PMID: 23600922; PubMed Central PMCID: PMC3674550. </br>2: Harrison E, Coulter JA, Dixon D. Gold nanoparticle surface functionalization: mixed monolayer versus hetero bifunctional peg linker. Nanomedicine (Lond). 2016 Apr;11(7):851-65. Review. PubMed PMID: 27021417.</br>3: Augusto MT, Hollmann A, Porotto M, Moscona A, Santos NC. Antiviral Lipopeptide-Cell Membrane Interaction Is Influenced by PEG Linker Length. Molecules. 2017 Jul 15;22(7). pii: E1190. doi: 10.3390/molecules22071190. PubMed PMID: 28714870; PubMed Central PMCID: PMC5776016.</br>4: Tuma R, Russell M, Rosendahl M, Thomas GJ Jr. Solution conformation of the extracellular domain of the human tumor necrosis factor receptor probed by Raman and UV-resonance Raman spectroscopy: structural effects of an engineered PEG linker. Biochemistry. 1995 Nov 21;34(46):15150-6. PubMed PMID: 7578129. </br> </br> |
