Propargyl-PEG5-t-butyl ester

• CAT Number: I014633
• CAS Number: 1245823-50-0
• Molecular Formula: C18H32O7
• Molecular Weight: 360.45
• Purity: ≥95%
• Synonyms: Propargyl-PEG5-t-butyl ester;Propargyl-PEG5-t-butyl ester
• Target: PROTAC
• Solubility: Soluble in DMSO
• InChI: InChI=1S/C18H32O7/c1-5-7-20-9-11-22-13-15-24-16-14-23-12-10-21-8-6-17(19)25-18(2,3)4/h1H,6-16H2,2-4H3
• InChIKey: YPLMNICQRHSVNT-UHFFFAOYSA-N
• SMILES: O=C(OC(C)(C)C)CCOCCOCCOCCOCCOCC#C

Propargyl-PEG5-t-butyl ester is a PEG derivative containing a propargyl group and a t-butyl protected carboxyl group. The propargyl group can be reacted with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. The t-butyl protected carboxyl group can be deprotected under acidic conditions. The hydrophilic PEG spacer increases solubility in aqueous media.

Reference

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