Propargyl-PEG6-acid

• CAT Number: I014634
• CAS Number: 1951438-84-8
• Molecular Formula: C16H28O8
• Molecular Weight: 348.39
• Purity: ≥95%
• Synonyms: Propargyl-PEG6-acid;Propargyl-PEG6-acid
• Target: PROTAC
• Solubility: Soluble in DMSO
• IUPAC Name: 3-[2-[2-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
• InChI: InChI=1S/C16H28O8/c1-2-4-19-6-8-21-10-12-23-14-15-24-13-11-22-9-7-20-5-3-16(17)18/h1H,3-15H2,(H,17,18)
• InChIKey: XRSJYQQOJNYUDV-UHFFFAOYSA-N
• SMILES: OC(CCOCCOCCOCCOCCOCCOCC#C)=O

Propargyl-PEG6-acid(CAT: I014634) is a versatile polyethylene glycol (PEG) derivative featuring a terminal propargyl group and a carboxylic acid functional group. The terminal carboxylic acid enables coupling with primary amines in the presence of coupling agents like EDC or DCC to form stable amide bonds. The propargyl group participates in copper-catalyzed azide-alkyne cycloaddition (Click Chemistry) for conjugation with azide-bearing molecules, forming stable triazole linkages. The PEG6 spacer imparts hydrophilicity, enhancing solubility in aqueous systems and minimizing nonspecific interactions. Propargyl-PEG6-acid is widely used in bioconjugation, drug delivery, and the development of functionalized biomaterials, making it a valuable tool for chemical and biomedical research.