Propargyl-PEG7-acid

• CAT Number: I014639
• CAS Number: 2093154-00-6
• Molecular Formula: C18H32O9
• Molecular Weight: 392.45
• Purity: ≥95%
• Synonyms: Propargyl-PEG7-acid, Propyne-PEG6-CH2CH2COOH;Propargyl-PEG7-acid
• Target: PROTAC
• Solubility: Soluble in DMSO
• IUPAC Name: 3-[2-[2-[2-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
• InChI: InChI=1S/C18H32O9/c1-2-4-21-6-8-23-10-12-25-14-16-27-17-15-26-13-11-24-9-7-22-5-3-18(19)20/h1H,3-17H2,(H,19,20)
• InChIKey: VCXGERMSMMAGNQ-UHFFFAOYSA-N
• SMILES: OC(CCOCCOCCOCCOCCOCCOCCOCC#C)=O

Propargyl-PEG7-acid(CAT: I014639) is a versatile PEG derivative with a propargyl group and a terminal carboxylic acid. The terminal carboxylic acid reacts with primary amines in the presence of coupling agents like EDC or DCC, forming stable amide bonds. The hydrophilic PEG7 spacer enhances solubility in aqueous systems, making it suitable for bioconjugation and drug delivery applications. The propargyl group facilitates copper-catalyzed azide-alkyne cycloaddition (Click Chemistry) with azide-functionalized molecules, yielding stable triazole linkages. Propargyl-PEG7-acid is widely employed in the synthesis of biomolecule conjugates, surface modifications, and drug delivery systems, offering a flexible tool for chemical and biomedical research.