For research use only. Not for therapeutic Use.
Propargyl-PEG7-NHS ester（Cat No.:I014640）is a versatile chemical compound used in bioconjugation and chemical biology. It consists of a propargyl group (a terminal alkyne), a polyethylene glycol (PEG) linker with seven ethylene glycol units (PEG7), and a N-hydroxysuccinimide (NHS) ester functional group. The NHS ester reacts with amine groups (–NH2) on proteins, peptides, or other biomolecules to form stable covalent bonds. The propargyl group enables click chemistry reactions, such as copper-catalyzed azide-alkyne cycloaddition (CuAAC), for further functionalization or labeling. This compound is commonly used in drug delivery, protein labeling, and biomolecule modification.
| Catalog Number | I014640 |
| CAS Number | 2093152-77-1 |
| Synonyms | Propargyl-PEG7-NHS ester;Propargyl-PEG7-NHS ester |
| Molecular Formula | C22H35NO11 |
| Purity | ≥95% |
| Target | PROTAC |
| Solubility | Soluble in DMSO |
| IUPAC Name | (2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate |
| InChI | InChI=1S/C22H35NO11/c1-2-6-27-8-10-29-12-14-31-16-18-33-19-17-32-15-13-30-11-9-28-7-5-22(26)34-23-20(24)3-4-21(23)25/h1H,3-19H2 |
| InChIKey | ZVLITXJWZOQGHB-UHFFFAOYSA-N |
| SMILES | C#CCOCCOCCOCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O |
| Reference | </br>1: Sano K, Nakajima T, Miyazaki K, Ohuchi Y, Ikegami T, Choyke PL, Kobayashi H. Short PEG-linkers improve the performance of targeted, activatable monoclonal antibody-indocyanine green optical imaging probes. Bioconjug Chem. 2013 May 15;24(5):811-6. doi: 10.1021/bc400050k. Epub 2013 May 3. PubMed PMID: 23600922; PubMed Central PMCID: PMC3674550. </br>2: Harrison E, Coulter JA, Dixon D. Gold nanoparticle surface functionalization: mixed monolayer versus hetero bifunctional peg linker. Nanomedicine (Lond). 2016 Apr;11(7):851-65. Review. PubMed PMID: 27021417.</br>3: Augusto MT, Hollmann A, Porotto M, Moscona A, Santos NC. Antiviral Lipopeptide-Cell Membrane Interaction Is Influenced by PEG Linker Length. Molecules. 2017 Jul 15;22(7). pii: E1190. doi: 10.3390/molecules22071190. PubMed PMID: 28714870; PubMed Central PMCID: PMC5776016.</br>4: Tuma R, Russell M, Rosendahl M, Thomas GJ Jr. Solution conformation of the extracellular domain of the human tumor necrosis factor receptor probed by Raman and UV-resonance Raman spectroscopy: structural effects of an engineered PEG linker. Biochemistry. 1995 Nov 21;34(46):15150-6. PubMed PMID: 7578129. </br> </br> |
