Propargyl-PEG8-NHS ester

• CAT Number: I014645
• CAS Number: 2182601-74-5
• Molecular Formula: C24H39NO12
• Molecular Weight: 533.57
• Purity: ≥95%
• Synonyms: Propargyl-PEG8-NHS ester;Propargyl-PEG8-NHS ester
• Target: PROTAC
• Solubility: Soluble in DMSO
• IUPAC Name: (2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate
• InChI: InChI=1S/C24H39NO12/c1-2-6-29-8-10-31-12-14-33-16-18-35-20-21-36-19-17-34-15-13-32-11-9-30-7-5-24(28)37-25-22(26)3-4-23(25)27/h1H,3-21H2
• InChIKey: PFFLYBWAOVXONG-UHFFFAOYSA-N
• SMILES: C#CCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O

Propargyl-PEG8-NHS ester（Cat No.:I014645）is a bioconjugation reagent consisting of a polyethylene glycol (PEG) linker, an N-hydroxysuccinimide (NHS) ester, and a propargyl group. The NHS ester facilitates the attachment of the compound to primary amines on biomolecules like proteins or peptides, enabling the creation of stable conjugates for various applications. The propargyl group allows for further modification through click chemistry, such as copper-catalyzed reactions. This reagent is often used in drug delivery systems, molecular imaging, and the development of targeted therapies, as the PEG8 chain provides enhanced solubility and bioavailability in vivo.