For research use only. Not for therapeutic Use.
Propoxur（Cat No.:I000536）is a broad-spectrum carbamate insecticide used to control a variety of pests, including mosquitoes, cockroaches, flies, and fleas. It works by inhibiting acetylcholinesterase, an enzyme essential for nerve function, leading to the accumulation of acetylcholine and the disruption of nerve impulses in insects. This results in the paralysis and eventual death of the pest. Propoxur is commonly employed in residential and commercial pest control and in veterinary applications for flea and tick management. Its effectiveness and relatively low toxicity to humans make it a widely used insecticide.
| Catalog Number | I000536 |
| CAS Number | 114-26-1 |
| Molecular Formula | C11H15NO3 |
| Purity | ≥95% |
| Target | Fungal |
| Solubility | 10 mM in DMSO |
| Storage | Store at -20°C |
| IUPAC Name | (2-propan-2-yloxyphenyl) N-methylcarbamate |
| InChI | InChI=1S/C11H15NO3/c1-8(2)14-9-6-4-5-7-10(9)15-11(13)12-3/h4-8H,1-3H3,(H,12,13) |
| InChIKey | ISRUGXGCCGIOQO-UHFFFAOYSA-N |
| SMILES | CC(C)OC1=CC=CC=C1OC(=O)NC |
| Reference | </br>1:Propoxur-induced oxidative DNA damage in human peripheral blood mononuclear cells: protective effects of curcumin and α-tocopherol. Ahmed T, Goel V, Banerjee BD.Drug Chem Toxicol. 2017 May 15:1-7. doi: 10.1080/01480545.2017.1321010. [Epub ahead of print] PMID: 28504020 </br>2:Subchronic toxicity of low dose propoxur, permethrin, and their combination on the redox status of rat liver. Wang P, Xu MY, Liang YJ, Wang HP, Sun YJ, Long DX, Wu YJ.Chem Biol Interact. 2017 Apr 26;272:21-27. doi: 10.1016/j.cbi.2017.04.023. [Epub ahead of print] PMID: 28456543 </br>3:Degradation of the insecticide propoxur by electrochemical advanced oxidation processes using a boron-doped diamond/air-diffusion cell. Guelfi DR, Gozzi F, Sirés I, Brillas E, Machulek A Jr, de Oliveira SC.Environ Sci Pollut Res Int. 2017 Mar;24(7):6083-6095. doi: 10.1007/s11356-016-6416-8. Epub 2016 Mar 17. PMID: 26983915 </br>4:Inheritance of Propoxur Resistance in a Near-Isogenic Line of Musca domestica (Diptera: Muscidae). Shan C, Zhang Y, Ma Z, Gao X.J Econ Entomol. 2016 Apr;109(2):873-8. PMID: 26921225 </br>5:Identification of genes involved in pyrethroid-, propoxur-, and dichlorvos- insecticides resistance in the mosquitoes, Culex pipiens complex (Diptera: Culicidae). Li CX, Guo XX, Zhang YM, Dong YD, Xing D, Yan T, Wang G, Zhang HD, Zhao TY.Acta Trop. 2016 May;157:84-95. doi: 10.1016/j.actatropica.2016.01.019. Epub 2016 Jan 21. PMID: 26802491 Free Article</br>6:The urinary bladder carcinogen propoxur does not produce genotoxic effects in the urinary bladder of Wistar male rats. Iatropoulos MJ, Duan JD, Schmuck G, Williams GM.Exp Toxicol Pathol. 2015 Sep;67(9):453-8. doi: 10.1016/j.etp.2015.06.002. Epub 2015 Jul 8. PMID: 26164753 </br>7:Evaluation of the expression of P-glycoprotein in propoxur-resistant Caco-2 cells. Yazdian S, Fahham N, Ghahremani MH, Afzali M, Farsandaj N, Vatankhah M, Ostad SN.Acta Med Iran. 2014;52(10):728-33. PMID: 25369005 Free Article</br>8:Application of an optimized dispersive nanomaterial ultrasound-assisted microextraction method for preconcentration of carbofuran and propoxur and their determination by high-performance liquid chromatography with UV detection. Khodadoust S, Talebianpoor MS, Ghaedi M.J Sep Sci. 2014 Nov;37(21):3117-24. doi: 10.1002/jssc.201400816. Epub 2014 Sep 18. PMID: 25234016 </br>9:Application of third-order multivariate calibration algorithms to the determination of carbaryl, naphthol and propoxur by kinetic spectroscopic measurements. Santa-Cruz P, García-Reiriz A.Talanta. 2014 Oct;128:450-9. doi: 10.1016/j.talanta.2014.04.075. Epub 2014 May 6. PMID: 25059185 </br>10:[Malathion and propoxur resistance in Turkish populations of the Anopheles maculipennis Meigen (Diptera: Culicidae) and relation to the insensitive acetylcholinesterase]. Akıner MM.Turkiye Parazitol Derg. 2014 Jun;38(2):111-5. doi: 10.5152/tpd.2014.3388. Turkish. PMID: 25016118 Free Article |
