For research use only. Not for therapeutic Use.
Propranolol (CAT: I018757) is a non-selective beta-adrenergic receptor antagonist, commonly known as a beta-blocker. It works by blocking the action of epinephrine and norepinephrine on beta receptors in the heart and blood vessels, resulting in decreased heart rate, reduced blood pressure, and decreased oxygen demand by the heart. Propranolol is used in the management of various cardiovascular conditions, including hypertension, angina pectoris, and arrhythmias. Additionally, it has been employed for the treatment of anxiety disorders, migraine headaches, and essential tremors. Propranolol’s broad pharmacological profile and established safety make it a versatile and widely prescribed medication in clinical practice.
| Catalog Number | I018757 |
| CAS Number | 525-66-6 |
| Molecular Formula | C₁₆H₂₁NO₂ |
| Purity | ≥95% |
| Reference | [1]. Galandrin S, et al. Distinct signaling profiles of beta1 and beta2 adrenergic receptor ligands toward adenylyl cyclase and mitogen-activated protein kinase reveals the pluridimensionality of efficacy. Mol Pharmacol. 2006 Nov;70(5):1575-84. Epub 2006 Aug 1<br>[2]. Briley M, et al. Evidence against beta-adrenoceptor blocking activity of diltiazem, a drug with calcium antagonist properties. Br J Pharmacol. 1980 Aug;69(4):669-73.<br>[3]. Al-Majed AA, et al. Propranolol. Profiles Drug Subst Excip Relat Methodol. 2017;42:287-338.<br>[4]. Munabi NC, et al. Propranolol Targets Hemangioma Stem Cells via cAMP and Mitogen-Activated Protein Kinase Regulation. Stem Cells Transl Med. 2016 Jan;5(1):45-55. |
