Propynol Ethoxylate

• CAT Number: R017932
• CAS Number: 3973-18-0
• Molecular Formula: C5H8O2
• Molecular Weight: 100.12
• Purity: ≥95%
• Synonyms: 2-prop-2-ynoxyethanol
• InChI: InChI=1S/C5H8O2/c1-2-4-7-5-3-6/h1,6H,3-5H2
• InChIKey: GHGCQQRMJCSIBQ-UHFFFAOYSA-N
• SMILES: C#CCOCCO

Propynol Ethoxylate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propynol Ethoxylate is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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