For research use only. Not for therapeutic Use.
Prostaglandin E<sub>2</sub> methyl ester (PGE<sub>2</sub> methyl ester) is an analog of PGE<sub>2</sub> (Item No. <span class=/itemid/>14010</span>) with enhanced lipid solubility. PGE<sub>2</sub> is one of the primary cyclooxygenase products of arachidonic acid (Item No. <span class=/itemid/>90010</span>) and one of the most widely investigated PGs. Its activity influences inflammation, fertility and parturition, gastric mucosal integrity, and immune modulation. The effects of PGE<sub>2</sub> are transduced by at least four distinct receptors designated EP<sub>1</sub>, EP<sub>2</sub>, EP<sub>3</sub>, and EP<sub>4</sub>. Affinity constants (K<sub>d</sub>) values of PGE<sub>2</sub> for these receptors range from 1-10 nM depending on the receptor subtype and tissue.
| Catalog Number | R064591 |
| CAS Number | 31753-17-0 |
| Synonyms | Dinoprostone methyl ester;PGE2 methyl ester |
| Molecular Formula | C21H34O5 |
| Purity | ≥95% |
| Storage | -20°C |
| InChI | InChI=1S/C21H34O5/c1-3-4-7-10-16(22)13-14-18-17(19(23)15-20(18)24)11-8-5-6-9-12-21(25)26-2/h5,8,13-14,16-18,20,22,24H,3-4,6-7,9-12,15H2,1-2H3/b8-5-,14-13+/t16-,17+,18+,20+/m0/s1 |
| InChIKey | WGCXTGBZBFBQPP-ZYONDNFOSA-N |
| SMILES | O=C1[C@H](C/C=CCCCC(OC)=O)[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C1 |
| Reference | 1.Willis, A.L., and Cornelsen, M. Repeated injection of prostaglandin E2 in rat paws induces chronic swelling and a marked decrease in pain threshold. Prostaglandins 3, 353-357 (1973). |
