For research use only. Not for therapeutic Use.
Prostaglandin F<sub>1α</sub> (PGF<sub>1α</sub>) is the putative metabolite of dihomo-<wbr></wbr>γ-<wbr></wbr>linolenic acid (DGLA) <em>via</em> the cyclooxygenase (COX) pathway. Both PGF<sub>1α</sub> and PGF<sub>2α</sub> have been shown to act as priming pheromones for male Atlantic salmon with a threshold concentration of 10 PGF<sub>1α</sub> binds to the ovine corpus luteum FP receptor at only 8% of the relative potency of PGF<sub>2α</sub>. It is only half as active as PGF<sub>2α</sub> in inducing human respiratory smooth muscle contractions <em>in vitro</em>.
| Catalog Number | R064949 |
| CAS Number | 745-62-0 |
| Synonyms | PGF1α |
| Molecular Formula | C20H36O5 |
| Purity | ≥95% |
| Target | Prostaglandin Receptor |
| Storage | -20°C |
| IUPAC Name | 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]cyclopentyl]heptanoic acid |
| InChI | InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1 |
| InChIKey | DZUXGQBLFALXCR-CDIPTNKSSA-N |
| SMILES | CCCCCC(C=CC1C(CC(C1CCCCCCC(=O)O)O)O)O |
| Reference | 1.Moore, A., and Waring, C.P. Electrophysiological and endocrinological evidence that F-series prostaglandins function as priming pheromones in mature male Atlantic salmon (Salmo salar) PARR. Journal of Experimental Biology 199, 2307-2316 (1996). |
