Prostaglandin H2 Lipid Maps® MS Standard

• CAT Number: R015281
• Molecular Formula: C20H32O5
• Molecular Weight: 352.5
• Purity: ≥95%
• Synonyms: PGH2
• Storage: -80°C

Prostaglandin H2 (PGH2) was first isolated from incubations of arachidonic acid with ovine seminal vesicle microsomes, and was described as a potent vasoconstrictor. PGH2 is the precursor for all 2-<wbr></wbr>series PGs and thromboxanes (TXs), and is a TP receptor agonist which irreversibly aggregates human platelets at 50-<wbr></wbr>100 ng/ml. PGH2 is a suicide substrate for platelet TX synthase possessing a Ki of 18 µM as compared to 28 µM for PGH1.

Reference

1.Hamberg, M.,Svensson, J.,Wakabayashi, T., et al. Isolation and structure of two prostaglandin endoperoxides that cause platelet aggregation. Proceedings of the National Academy of Sciences of the United States of America 71, 345-349 (1974).