For research use only. Not for therapeutic Use.
Prostaglandin H<sub>2</sub> (PGH<sub>2</sub>) was first isolated from incubations of arachidonic acid with ovine seminal vesicle microsomes, and was described as a potent vasoconstrictor. PGH<sub>2</sub> is the precursor for all 2-<wbr></wbr>series PGs and thromboxanes (TXs), and is a TP receptor agonist which irreversibly aggregates human platelets at 50-<wbr></wbr>100 ng/ml.
| Catalog Number | R065252 |
| CAS Number | 42935-17-1 |
| Synonyms | PGH2 |
| Molecular Formula | C20H32O5 |
| Purity | ≥95% |
| Storage | -80°C |
| IUPAC Name | (Z)-7-[(1S,4R,5R,6R)-5-[(E,3S)-3-hydroxyoct-1-enyl]-2,3-dioxabicyclo[2.2.1]heptan-6-yl]hept-5-enoic acid |
| InChI | InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 |
| InChIKey | YIBNHAJFJUQSRA-YNNPMVKQSA-N |
| SMILES | CCCCCC(C=CC1C2CC(C1CC=CCCCC(=O)O)OO2)O |
| Reference | 1.Hamberg, M.,Svensson, J.,Wakabayashi, T., et al. Isolation and structure of two prostaglandin endoperoxides that cause platelet aggregation. Proceedings of the National Academy of Sciences of the United States of America 71, 345-349 (1974). |
