For research use only. Not for therapeutic Use.
PGK<sub>1</sub> is the 9,11-<wbr></wbr>diketone formed by the oxidation of PGE<sub>1</sub> or PGD<sub>1</sub>. Whether this compound exists biologically is uncertain; it is known to be resistant to metabolism by 15-<wbr></wbr>hydroxy PGDH <em>in vitro</em>. In an intact porcine model of balloon angioplasty restenosis, PGK<sub>1</sub> was equivalent in activity and potency to PGE<sub>1</sub>.
| Catalog Number | R065937 |
| CAS Number | 69413-73-6 |
| Synonyms | PGK1 |
| Molecular Formula | C20H32O5 |
| Purity | ≥95% |
| Storage | -20°C |
| IUPAC Name | 7-[(1R,2R)-2-[(E,3S)-3-hydroxyoct-1-enyl]-3,5-dioxocyclopentyl]heptanoic acid |
| InChI | InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,21H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+/m0/s1 |
| InChIKey | KJWZYMMLVHIVSU-IYCNHOCDSA-N |
| SMILES | CCCCCC(C=CC1C(C(=O)CC1=O)CCCCCCC(=O)O)O |
| Reference | 1.Ohno, H.,Morikawa, Y. and Hirata, F. Studies on 15-hydroxyprostaglandin dehydrogenase with various prostaglandin analogues. Journal of Biochemistry 84, 1485-1494 (1978). |
