For research use only. Not for therapeutic Use.
PROTAC BRAF-V600E degrader-1（Cat No.:I042931）is a novel bifunctional small molecule designed to selectively degrade the BRAF-V600E mutant protein, which is commonly implicated in various cancers, particularly melanoma. PROTAC (Proteolysis Targeting Chimera) technology utilizes two distinct ligands: one that binds to BRAF-V600E and another that recruits the E3 ubiquitin ligase, leading to the targeted degradation of the protein. By specifically inducing the breakdown of BRAF-V600E, this degrader aims to inhibit cancer cell growth and survival, offering a promising therapeutic strategy for cancers driven by this mutation. It is currently undergoing preclinical studies.
| CAS Number | 2417296-84-3 |
| Synonyms | N-[3-[5-[[1-[3-[2-[2-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]propanoyl]piperidin-4-yl]-methylamino]-3-pyrimidin-5-ylpyrrolo[3,2-b]pyridin-1-yl]-2,4-difluorophenyl]propane-1-sulfonamide |
| Molecular Formula | C48H54F2N10O10S |
| Purity | ≥95% |
| IUPAC Name | N-[3-[5-[[1-[3-[2-[2-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]propanoyl]piperidin-4-yl]-methylamino]-3-pyrimidin-5-ylpyrrolo[3,2-b]pyridin-1-yl]-2,4-difluorophenyl]propane-1-sulfonamide |
| InChI | InChI=1S/C48H54F2N10O10S/c1-3-25-71(66,67)56-36-8-7-34(49)45(43(36)50)59-28-33(30-26-51-29-52-27-30)44-37(59)9-11-39(54-44)57(2)31-13-17-58(18-14-31)41(62)15-19-68-21-23-70-24-22-69-20-16-53-35-6-4-5-32-42(35)48(65)60(47(32)64)38-10-12-40(61)55-46(38)63/h4-9,11,26-29,31,38,53,56H,3,10,12-25H2,1-2H3,(H,55,61,63) |
| InChIKey | FMUGAZVOOIUFAT-UHFFFAOYSA-N |
| SMILES | CCCS(=O)(=O)NC1=C(C(=C(C=C1)F)N2C=C(C3=C2C=CC(=N3)N(C)C4CCN(CC4)C(=O)CCOCCOCCOCCNC5=CC=CC6=C5C(=O)N(C6=O)C7CCC(=O)NC7=O)C8=CN=CN=C8)F |
