For research use only. Not for therapeutic Use.
PROTAC BRD4 Degrader-19（Cat No.:I041154）is a small molecule compound designed to selectively degrade BRD4, a member of the BET (bromodomain and extraterminal) family of proteins. BRD4 plays a critical role in regulating gene transcription and is implicated in various cancers, particularly those with elevated transcriptional activity. This PROTAC (proteolysis-targeting chimera) utilizes a bifunctional approach, recruiting the cellular E3 ubiquitin ligase to BRD4, promoting its ubiquitination, and leading to its degradation. PROTAC BRD4 Degrader-19 holds potential as a targeted therapeutic for treating cancers driven by BRD4 overexpression or dysregulation.
| CAS Number | 2684292-71-3 |
| Synonyms | methyl 2-[(9S)-7-[4-[4-[[4-[(3-cyano-4-methyl-1H-indol-7-yl)sulfamoyl]phenyl]methylcarbamoyl]phenyl]phenyl]-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetate |
| Molecular Formula | C44H38N8O5S2 |
| Purity | ≥95% |
| IUPAC Name | methyl 2-[(9S)-7-[4-[4-[[4-[(3-cyano-4-methyl-1H-indol-7-yl)sulfamoyl]phenyl]methylcarbamoyl]phenyl]phenyl]-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetate |
| InChI | InChI=1S/C44H38N8O5S2/c1-24-6-19-35(41-38(24)33(21-45)23-46-41)51-59(55,56)34-17-7-28(8-18-34)22-47-43(54)32-15-11-30(12-16-32)29-9-13-31(14-10-29)40-39-25(2)26(3)58-44(39)52-27(4)49-50-42(52)36(48-40)20-37(53)57-5/h6-19,23,36,46,51H,20,22H2,1-5H3,(H,47,54)/t36-/m0/s1 |
| InChIKey | HHSZFSOLNUHGMP-BHVANESWSA-N |
| SMILES | CC1=C2C(=CNC2=C(C=C1)NS(=O)(=O)C3=CC=C(C=C3)CNC(=O)C4=CC=C(C=C4)C5=CC=C(C=C5)C6=N[C@H](C7=NN=C(N7C8=C6C(=C(S8)C)C)C)CC(=O)OC)C#N |
