For research use only. Not for therapeutic Use.
PROTAC BRD9 Degrader-6(CAT: I040924) is a proteolysis-targeting chimera (PROTAC) designed to selectively induce the degradation of BRD9, a member of the bromodomain and extra-terminal (BET) protein family. BRD9 plays a role in chromatin remodeling and gene transcription, and its dysregulation is implicated in various cancers and neurological diseases. PROTAC BRD9 Degrader-6 recruits the cellular E3 ligase machinery to facilitate the targeted degradation of BRD9, thereby inhibiting its function. This compound is highly relevant for Cancer Disease Research and Neurological Disease Research, offering a potential therapeutic strategy to target BRD9 in diseases driven by aberrant chromatin regulation.
| CAS Number | 2676211-62-2 |
| Synonyms | 3-[5-[7-[[1-[[4-[6-(azetidin-1-yl)-2-methyl-1-oxo-2,7-naphthyridin-4-yl]-2,6-dimethoxyphenyl]methyl]piperidin-4-yl]methyl]-2,7-diazaspiro[3.5]nonan-2-yl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione |
| Molecular Formula | C47H56N8O6 |
| Purity | ≥95% |
| IUPAC Name | 3-[5-[7-[[1-[[4-[6-(azetidin-1-yl)-2-methyl-1-oxo-2,7-naphthyridin-4-yl]-2,6-dimethoxyphenyl]methyl]piperidin-4-yl]methyl]-2,7-diazaspiro[3.5]nonan-2-yl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione |
| InChI | InChI=1S/C47H56N8O6/c1-50-26-37(35-22-42(53-13-4-14-53)48-23-36(35)45(50)58)32-19-40(60-2)38(41(20-32)61-3)27-51-15-9-30(10-16-51)24-52-17-11-47(12-18-52)28-54(29-47)33-6-5-31-25-55(46(59)34(31)21-33)39-7-8-43(56)49-44(39)57/h5-6,19-23,26,30,39H,4,7-18,24-25,27-29H2,1-3H3,(H,49,56,57) |
| InChIKey | OBNRBCUHEAAFPS-UHFFFAOYSA-N |
| SMILES | CN1C=C(C2=CC(=NC=C2C1=O)N3CCC3)C4=CC(=C(C(=C4)OC)CN5CCC(CC5)CN6CCC7(CC6)CN(C7)C8=CC9=C(CN(C9=O)C1CCC(=O)NC1=O)C=C8)OC |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
