PROTAC CDK9 Degrader-1

• CAT Number: I020349
• CAS Number: 2118356-96-8
• Molecular Formula: C₃₃H₃₅N₅O₇
• Molecular Weight: 613.66
• Purity: ≥95%
• Target: Cell Cycle/DNA Damage
• Storage: Store at -20°C
• IUPAC Name: N-(5-cyclobutyl-1H-pyrazol-3-yl)-2-[4-[5-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxypentoxy]phenyl]acetamide
• InChI: InChI=1S/C33H35N5O7/c39-28-15-14-25(31(41)35-28)38-32(42)23-8-5-9-26(30(23)33(38)43)45-17-3-1-2-16-44-22-12-10-20(11-13-22)18-29(40)34-27-19-24(36-37-27)21-6-4-7-21/h5,8-13,19,21,25H,1-4,6-7,14-18H2,(H,35,39,41)(H2,34,36,37,40)
• InChIKey: WCEHIDWONYOKOJ-UHFFFAOYSA-N
• SMILES: C1CC(C1)C2=CC(=NN2)NC(=O)CC3=CC=C(C=C3)OCCCCCOC4=CC=CC5=C4C(=O)N(C5=O)C6CCC(=O)NC6=O

PROTAC CDK9 Degrader-1（Cat No.:I020349） is a compound designed to selectively degrade cyclin-dependent kinase 9 (CDK9), a protein involved in cell cycle regulation and transcriptional control. By utilizing a proteolysis-targeting chimera (PROTAC) approach, CDK9 Degrader-1 recruits CDK9 to the cellular protein degradation machinery, leading to its targeted degradation. This selective degradation of CDK9 can modulate its activity and downstream signaling pathways, potentially offering therapeutic benefits in diseases where CDK9 dysregulation is implicated, such as certain cancers and inflammatory disorders.

Reference

[1]. Robb CM, et al. Chemically induced degradation of CDK9 by a proteolysis targeting chimera (PROTAC). Chem Commun (Camb). 2017 Jul 4;53(54):7577-7580.