For research use only. Not for therapeutic Use.
PROTAC CDK9 degrader-7（Cat No.:I041225）is a targeted protein degradation compound designed to selectively degrade cyclin-dependent kinase 9 (CDK9). CDK9 is a key regulator of transcriptional elongation, and its dysregulation is implicated in various cancers. By utilizing the PROTAC (proteolysis-targeting chimera) technology, PROTAC CDK9 degrader-7 recruits the cellular ubiquitin-proteasome system to selectively tag CDK9 for degradation, thereby reducing its activity. This compound offers a novel therapeutic strategy in oncology, aiming to disrupt CDK9-driven transcriptional processes. It is being researched for its potential in treating cancers with abnormal CDK9 signaling.
| CAS Number | 2935587-90-7 |
| Synonyms | 4-[(2,6-dichlorobenzoyl)amino]-N-[1-[12-[[2-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxyacetyl]amino]dodecanoyl]piperidin-4-yl]-1H-pyrazole-5-carboxamide |
| Molecular Formula | C43H50Cl2N8O9 |
| Purity | ≥95% |
| IUPAC Name | 4-[(2,6-dichlorobenzoyl)amino]-N-[1-[12-[[2-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxyacetyl]amino]dodecanoyl]piperidin-4-yl]-1H-pyrazole-5-carboxamide |
| InChI | InChI=1S/C43H50Cl2N8O9/c44-28-13-11-14-29(45)37(28)40(58)49-30-24-47-51-38(30)41(59)48-26-19-22-52(23-20-26)35(56)16-8-6-4-2-1-3-5-7-9-21-46-34(55)25-62-32-15-10-12-27-36(32)43(61)53(42(27)60)31-17-18-33(54)50-39(31)57/h10-15,24,26,31H,1-9,16-23,25H2,(H,46,55)(H,47,51)(H,48,59)(H,49,58)(H,50,54,57) |
| InChIKey | VOTFYHWCGUFSOV-UHFFFAOYSA-N |
| SMILES | C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)OCC(=O)NCCCCCCCCCCCC(=O)N4CCC(CC4)NC(=O)C5=C(C=NN5)NC(=O)C6=C(C=CC=C6Cl)Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
