For research use only. Not for therapeutic Use.
PROTAC eDHFR Degrader-1 is a PROTAC that is effective degradation of eDHFR-YFP, various POIs-including YFP and Luciferase[1].
| Catalog Number | I040604 |
| CAS Number | 2849442-92-6 |
| Synonyms | 4-[4-[(2,4-diaminopyrimidin-5-yl)methyl]-2,6-dimethoxyphenoxy]-N-[2-[2-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]ethoxy]ethoxy]ethyl]butanamide |
| Molecular Formula | C36H44N8O10 |
| Purity | ≥95% |
| InChI | InChI=1S/C36H44N8O10/c1-50-26-18-21(17-22-20-41-36(38)43-32(22)37)19-27(51-2)31(26)54-12-4-7-28(45)40-11-14-53-16-15-52-13-10-39-24-6-3-5-23-30(24)35(49)44(34(23)48)25-8-9-29(46)42-33(25)47/h3,5-6,18-20,25,39H,4,7-17H2,1-2H3,(H,40,45)(H,42,46,47)(H4,37,38,41,43) |
| InChIKey | PJVJIKUHLULMOV-UHFFFAOYSA-N |
| SMILES | COC1=CC(=CC(=C1OCCCC(=O)NCCOCCOCCNC2=CC=CC3=C2C(=O)N(C3=O)C4CCC(=O)NC4=O)OC)CC5=CN=C(N=C5N)N |
| Reference | [1]. Jean M. Etersque, Regulation of eDHFR-tagged proteins with trimethoprim PROTACs.Nat Commun. 2023; 14: 7071. |
