For research use only. Not for therapeutic Use.
PROTAC EZH2 Degrader-1（Cat No.:I043512）is a proteolysis-targeting chimera (PROTAC) designed to selectively degrade EZH2, a histone methyltransferase involved in gene silencing and regulation of stem cell properties. EZH2 plays a crucial role in cancer progression, particularly in hematological malignancies such as lymphoma and leukemia, by promoting tumor cell proliferation. By recruiting the cellular degradation machinery to target EZH2, PROTAC EZH2 Degrader-1 effectively reduces EZH2 protein levels and disrupts its oncogenic function. This compound is being studied for its potential therapeutic applications in treating cancers driven by EZH2 overexpression or mutation.
| CAS Number | 2641601-67-2 |
| Synonyms | N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-5-[4-[[4-[7-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxyheptyl]piperazin-1-yl]methyl]phenyl]-3-[ethyl(oxan-4-yl)amino]-2-methylbenzamide |
| Molecular Formula | C54H67N7O8 |
| Purity | ≥95% |
| IUPAC Name | N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-5-[4-[[4-[7-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxyheptyl]piperazin-1-yl]methyl]phenyl]-3-[ethyl(oxan-4-yl)amino]-2-methylbenzamide |
| InChI | InChI=1S/C54H67N7O8/c1-5-60(41-20-28-68-29-21-41)46-32-40(31-43(37(46)4)50(63)55-33-44-35(2)30-36(3)56-51(44)64)39-16-14-38(15-17-39)34-59-25-23-58(24-26-59)22-9-7-6-8-10-27-69-47-13-11-12-42-49(47)54(67)61(53(42)66)45-18-19-48(62)57-52(45)65/h11-17,30-32,41,45H,5-10,18-29,33-34H2,1-4H3,(H,55,63)(H,56,64)(H,57,62,65) |
| InChIKey | LONVYJSHGSZBQY-UHFFFAOYSA-N |
| SMILES | CCN(C1CCOCC1)C2=CC(=CC(=C2C)C(=O)NCC3=C(C=C(NC3=O)C)C)C4=CC=C(C=C4)CN5CCN(CC5)CCCCCCCOC6=CC=CC7=C6C(=O)N(C7=O)C8CCC(=O)NC8=O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
