PROTAC FKBP Degrader-3

• CAT Number: I016232
• CAS Number: 2079056-43-0
• Molecular Formula: C₆₈H₉₀N₆O₁₇S
• Molecular Weight: 1295.54
• Purity: ≥95%
• Target: Immunology/Inflammation

PROTAC FKBP Degrader-3 (Cat.No:I016232) is a PROTAC that comprises a FKBP ligand binding group, a linker and an VHL binding group. PROTAC FKBP Degrader-3 is a potent FKBP degrader[1].PROTAC treatment time courses demonstrated a notable increase in polyubiquitination of EGFP-FKBP in response to treatment with 250 nM of PROTAC FKBP Degrader-3 (compound 10) for VHL within the first hour. Upon recruiting endogenous VHL via PROTAC FKBP Degrader-3 (compound 10), only one EGFP background lysine (Lys158) is found to be ubiquitylated[1].

Reference

[1]. Ottis P, et al. Assessing Different E3 Ligases for Small Molecule Induced Protein Ubiquitination and Degradation. ACS Chem Biol. 2017 Oct 20;12(10):2570-2578.