PROTAC FLT-3 degrader 1

• CAT Number: I019066
• CAS Number: 2230826-81-8
• Molecular Formula: C₅₂H₆₁N₉O₉S₂
• Molecular Weight: 1020.23
• Purity: ≥95%
• Target: Protein Tyrosine Kinase/RTK
• IUPAC Name: (2S,4R)-1-[(2S)-2-[3-[2-[2-[2-[4-[(5-tert-butyl-1,2-oxazol-3-yl)carbamoylamino]phenyl]imidazo[2,1-b][1,3]benzothiazol-6-yl]oxyethoxy]ethoxy]propanoylamino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide
• InChI: InChI=1S/C52H61N9O9S2/c1-31-45(71-30-54-31)34-10-8-32(9-11-34)27-53-47(64)40-24-36(62)28-60(40)48(65)46(52(5,6)7)58-44(63)18-19-67-20-21-68-22-23-69-37-16-17-39-41(25-37)72-50-56-38(29-61(39)50)33-12-14-35(15-13-33)55-49(66)57-43-26-42(70-59-43)51(2,3)4/h8-17,25-26,29-30,36,40,46,62H,18-24,27-28H2,1-7H3,(H,53,64)(H,58,63)(H2,55,57,59,66)/t36-,40+,46-/m1/s1
• InChIKey: IKJBYQODYFQASC-YKCITUTQSA-N
• SMILES: CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)CCOCCOCCOC4=CC5=C(C=C4)N6C=C(N=C6S5)C7=CC=C(C=C7)NC(=O)NC8=NOC(=C8)C(C)(C)C)O

PROTAC FLT-3 Degrader 1(CAT: I019066) is a novel and highly specific PROTAC (Proteolysis Targeting Chimera) molecule designed to selectively target and degrade FLT-3, a receptor tyrosine kinase implicated in acute myeloid leukemia (AML) and other hematological malignancies. By harnessing the ubiquitin-proteasome system, this compound facilitates the degradation of FLT-3, offering a unique approach to disrupt aberrant signaling pathways associated with cancer progression. With high purity and robust activity, PROTAC FLT-3 Degrader 1 is ideal for in vitro and in vivo studies, supporting research into targeted protein degradation and the development of next-generation cancer therapeutics.