For research use only. Not for therapeutic Use.
PROTAC GPX4 degrader-1（Cat No.:I041191）is an investigational compound designed to target and degrade the GPX4 (glutathione peroxidase 4) protein using the PROTAC (proteolysis-targeting chimera) technology. GPX4 is an antioxidant enzyme that plays a crucial role in preventing lipid peroxidation and cell death. By degrading GPX4, this compound aims to induce ferroptosis, a form of regulated cell death, in cancer cells. PROTAC GPX4 degrader-1 shows potential in treating cancers with GPX4 overexpression, particularly those resistant to traditional therapies. Ongoing research is evaluating its safety, efficacy, and potential therapeutic applications in oncology.
| CAS Number | 2916433-81-1 |
| Synonyms | 4-[3-[4-[[1-[2-[4-[(4-chlorophenyl)-[4-(5-methyl-4-nitro-1,2-oxazole-3-carbonyl)piperazin-1-yl]methyl]phenoxy]acetyl]piperidin-4-yl]methyl]piperazin-1-yl]propylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione |
| Molecular Formula | C50H57ClN10O10 |
| Purity | ≥95% |
| IUPAC Name | 4-[3-[4-[[1-[2-[4-[(4-chlorophenyl)-[4-(5-methyl-4-nitro-1,2-oxazole-3-carbonyl)piperazin-1-yl]methyl]phenoxy]acetyl]piperidin-4-yl]methyl]piperazin-1-yl]propylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione |
| InChI | InChI=1S/C50H57ClN10O10/c1-32-45(61(68)69)44(54-71-32)50(67)59-28-26-58(27-29-59)46(34-6-10-36(51)11-7-34)35-8-12-37(13-9-35)70-31-42(63)57-20-16-33(17-21-57)30-56-24-22-55(23-25-56)19-3-18-52-39-5-2-4-38-43(39)49(66)60(48(38)65)40-14-15-41(62)53-47(40)64/h2,4-13,33,40,46,52H,3,14-31H2,1H3,(H,53,62,64) |
| InChIKey | HMSNFNLFZRKDIO-UHFFFAOYSA-N |
| SMILES | CC1=C(C(=NO1)C(=O)N2CCN(CC2)C(C3=CC=C(C=C3)OCC(=O)N4CCC(CC4)CN5CCN(CC5)CCCNC6=CC=CC7=C6C(=O)N(C7=O)C8CCC(=O)NC8=O)C9=CC=C(C=C9)Cl)[N+](=O)[O-] |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
