PROTAC KRAS G12C degrader-2

• CAT Number: I041065
• CAS Number: 2378257-72-6
• Molecular Formula: C51H53ClFN9O7
• Molecular Weight: 958.47
• Purity: ≥95%
• Synonyms: 5-[4-[[4-[(2R)-2-[6-chloro-8-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-(4-prop-2-enoylpiperazin-1-yl)quinazolin-2-yl]oxypropyl]piperazin-1-yl]methyl]piperidin-1-yl]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
• InChI: InChI=1S/C51H53ClFN9O7/c1-3-43(65)60-20-22-61(23-21-60)47-39-27-40(52)44(37-26-34(63)24-32-6-4-5-7-35(32)37)45(53)46(39)55-51(56-47)69-30(2)28-57-16-18-58(19-17-57)29-31-12-14-59(15-13-31)33-8-9-36-38(25-33)50(68)62(49(36)67)41-10-11-42(64)54-48(41)66/h3-9,24-27,30-31,41,63H,1,10-23,28-29H2,2H3,(H,54,64,66)/t30-,41?/m1/s1
• InChIKey: KZQITCSEFGTWRQ-OWAVIYFHSA-N
• SMILES: CC(CN1CCN(CC1)CC2CCN(CC2)C3=CC4=C(C=C3)C(=O)N(C4=O)C5CCC(=O)NC5=O)OC6=NC7=C(C(=C(C=C7C(=N6)N8CCN(CC8)C(=O)C=C)Cl)C9=CC(=CC1=CC=CC=C19)O)F

PROTAC KRAS G12C degrader-2（Cat No.:I041065）is a small molecule drug designed to target and degrade the mutant KRAS G12C protein, a common driver of cancer, particularly in non-small cell lung cancer (NSCLC). This compound utilizes the PROTAC (PROteolysis TArgeting Chimeras) technology, which brings together the target protein and an E3 ligase to induce selective ubiquitination and proteasomal degradation of the KRAS G12C mutant. By specifically degrading the mutated protein rather than inhibiting its activity, PROTAC KRAS G12C degrader-2 offers a promising therapeutic approach for KRAS-driven cancers resistant to traditional treatments.