Proteasome-activating peptide 1 TFA

For research use only. Not for therapeutic Use.

  • CAT Number: I043792
  • Molecular Formula: C65H117F3N22O15S4
  • Molecular Weight: 1632.02
  • Purity: ≥95%
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Proteasome-activating peptide 1 TFA is a peptide and a potent proteasome activator. Proteasome-activating peptide 1 TFA increases the chymotrypsin-like proteasomal catalytic activity and, consequently, proteolytic rates both in vitro and in culture. Proteasome-activating peptide 1 TFA prevents protein aggregation in a cellular model of amyotrophic lateral sclerosis[1].
Proteasome-activating peptide 1 (TFA) (0-100 μM, 2 h) increases ChT-L catalytic activity of the 20S proteasome in a dose-dependent manner[1].
Proteasome-activating peptide 1 (TFA) (50 μM, 24 h) induces the degradation of SOD1, promotes a decrease of oxidized proteins[1].
Proteasome-activating peptide 1 (TFA) (0-100 μM) protects fibroblast and SH-SY5Y cells from oxidative stress[1].
Proteasome-activating peptide 1 (TFA) only affects the free 20S proteasomal pool[1].
Proteasome-activating peptide 1 (TFA) promotes proteasomal gate opening[1].


Catalog Number I043792
Molecular Formula C65H117F3N22O15S4
Purity ≥95%
Reference

[1]. Dal Vechio FH, et al. Peptides that activate the 20S proteasome by gate opening increased oxidized protein removal and reduced protein aggregation. Free Radic Biol Med. 2014;67:304-313.
 [Content Brief]

[2]. Dal Vechio FH, Cerqueira F, Augusto O, Lopes R, Demasi M. Peptides that activate the 20S proteasome by gate opening increased oxidized protein removal and reduced protein aggregation. Free Radic Biol Med. 2014 Feb;67:304-13.
 [Content Brief]

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