Protein kinase inhibitor H-7

• CAT Number: I043919
• CAS Number: 84477-87-2
• Molecular Formula: C14H17N3O2S
• Molecular Weight: 291.37
• Purity: ≥95%
• Synonyms: 5-(2-methylpiperazin-1-yl)sulfonylisoquinoline
• InChI: InChI=1S/C14H17N3O2S/c1-11-9-16-7-8-17(11)20(18,19)14-4-2-3-12-10-15-6-5-13(12)14/h2-6,10-11,16H,7-9H2,1H3
• InChIKey: BDVFVCGFMNCYPV-UHFFFAOYSA-N
• SMILES: CC1CNCCN1S(=O)(=O)C2=CC=CC3=C2C=CN=C3

Protein kinase inhibitor H-7 is a potent inhibitor of protein kinase C (PKC) and cyclic nucleotide dependent protein kinase, with a Ki of 6 μM for PKC[1].

Reference

[1]. Hidaka H, et, al. Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C. Biochemistry. 1984 Oct 9;23(21):5036-41.
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