Protirelin

• CAT Number: A000039
• CAS Number: 24305-27-9
• Molecular Formula: C16H22N6O4
• Molecular Weight: 362.39
• Purity: ≥95%
• Synonyms: Thyroliberin, Lopremone, Synthetic TRH, Thyrotropin-releasing hormone, Rifathyroin
• Target: Metabolic Enzyme/Protease
• Storage: Store at +4C
• IUPAC Name: (2S)-N-[(2S)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide
• InChI: InChI=1S/C16H22N6O4/c17-14(24)12-2-1-5-22(12)16(26)11(6-9-7-18-8-19-9)21-15(25)10-3-4-13(23)20-10/h7-8,10-12H,1-6H2,(H2,17,24)(H,18,19)(H,20,23)(H,21,25)/t10-,11-,12-/m0/s1
• InChIKey: XNSAINXGIQZQOO-SRVKXCTJSA-N
• SMILES: C1CC(N(C1)C(=O)C(CC2=CN=CN2)NC(=O)C3CCC(=O)N3)C(=O)N

Protirelin, also known as Thyrel TRH, is a thyrotropin-releasing hormone receptor used totreat hypothyroidism. Protirelin stimulates release of a hormone called thyroid-stimulating hormone, or TSH, from the anterior pituitary gland.

Reference

1: Duval F, Mokrani MC, Erb A, Gonzalez Opera F, Calleja C, Paris V. Relationship
between chronobiological thyrotropin and prolactin responses to protirelin (TRH)
and suicidal behavior in depressed patients. Psychoneuroendocrinology. 2017
Nov;85:100-109. doi: 10.1016/j.psyneuen.2017.07.488. Epub 2017 Jul 28. PubMed
PMID: 28843902.

2: Takei A, Hamada S, Homma S, Hamada K, Tashiro K, Hamada T. Amelioration of
subacute camptocormia in multiple system atrophy by protirelin tartrate. Mov
Disord. 2009 Oct 15;24(13):2022-3. doi: 10.1002/mds.22699. PubMed PMID: 19645068.

3: Nie Y, Schoepp DD, Klaunig JE, Yard M, Lahiri DK, Kubek MJ.
Thyrotropin-releasing hormone (protirelin) inhibits potassium-stimulated
glutamate and aspartate release from hippocampal slices in vitro. Brain Res. 2005
Aug 23;1054(1):45-54. PubMed PMID: 16055093.

4: Smyth DG, del Rio-Garcia J, Wallnöfer H, Gogl H, Simma W, Huber A, Embacher R,
Fraser H, Kreil G. Protirelin (thyrotropin-releasing hormone) in thyroid gland:
possible involvement in regulation of thyroid status. Zhongguo Yao Li Xue Bao.
1999 Apr;20(4):289-91. PubMed PMID: 10452110.

5: Marangell LB, George MS, Callahan AM, Ketter TA, Pazzaglia PJ, L/’Herrou TA,
Leverich GS, Post RM. Effects of intrathecal thyrotropin-releasing hormone
(protirelin) in refractory depressed patients. Arch Gen Psychiatry. 1997
Mar;54(3):214-22. PubMed PMID: 9075462.

6: Ciffo F, Bartoli V, Puglisi E, Scebba C, Munda M, Parisi W, Murgia P. [The
efficacy of protirelin in subjects with stabilized outcomes of stroke]. Clin Ter.
1996 Mar;147(3):123-9. Italian. PubMed PMID: 8767979.

7: Eulry F, Mayaudon H, Bauduceau B, Lechevalier D, Crozes P, Magnin J,
Claude-Berthelot C. [Blood prolactin under the effect of protirelin in
spondylarthropathies. Treatment trial of 4 cases of reactive arthritis and 2
cases of psoriatic arthritis with bromocriptine]. Ann Med Interne (Paris).
1996;147(1):15-9. French. PubMed PMID: 8763085.

8: Caraccio N, Monzani F, Casolaro A, Pucci E, Luisi M, Franchi F. [Tolerance of
long-term protirelin tartrate treatment]. Recenti Prog Med. 1995
Jun;86(6):226-30. Italian. PubMed PMID: 7624581.

9: Eulry F, Bauduceau B, Bouée S, Crozes P, Magnin J, Mayaudon H, Lechevalier D.
[Prolactin response to protirelin in reactive arthritis and ankylosing
spondyloarthritis. Failure of treatment of 4 reactive arthritis with
bromocriptine]. Rev Rhum Ed Fr. 1994 Dec;61(11):863-4. French. PubMed PMID:
7858584.

10: Garbutt JC, Mayo JP, Little KY, Gillette GM, Mason GA, Dew B, Prange AJ Jr.
Dose-response studies with protirelin. Arch Gen Psychiatry. 1994
Nov;51(11):875-83. PubMed PMID: 7944876.