Protocatechuic acid

• CAT Number: I005743
• CAS Number: 99-50-3
• Molecular Formula: C7H6O4
• Molecular Weight: 154.1
• Purity: ≥95%
• Synonyms: Protocatechuic acid; 3,4-Dihydroxybenzoic acid
• Target: Endogenous Metabolite
• Solubility: DMSO
• Storage: -20°C
• InChIKey: YQUVCSBJEUQKSH-UHFFFAOYSA-N

Protocatechuic acid is a phenolic compound which exhibits neuroprotective effects.

In Vitro: Protocatechuic acid inhibits the aggregation of Aβ and αS and destabilizes their preformed fibrils. Protocatechuic acid prevents the death of PC12 cells triggered by Aβ- and αS-induced toxicity.

Reference

[1]. Thakare VN, et al. Attenuation of acute restraint stress-induced depressive like behavior and hippocampal alterations with protocatechuic acid treatment in mice. Metab Brain Dis. 2016 Oct 26. 


[2]. Adefegha SA, et al. Alterations of Na+/K+-ATPase, cholinergic and antioxidant enzymes activity by protocatechuic acid in cadmium-induced neurotoxicity and oxidative stress in Wistar rats. Biomed Pharmacother. 2016 Oct;83:559-568. 


[3]. Hornedo-Ortega R, et al. Protocatechuic Acid: Inhibition of Fibril Formation, Destabilization of Preformed Fibrils of Amyloid-β and α-Synuclein, and Neuroprotection. J Agric Food Chem. 2016 Oct 10.