ProTx II TFA

• CAT Number: I040814
• Molecular Formula: C168H250N46O41S8.xC2HF3O2
• Molecular Weight: 3826.59 (free base)
• Purity: ≥95%

ProTx II TFA(CAT: I040814) is a potent and highly selective inhibitor of the Nav1.7 voltage–gated sodium channel, exhibiting an IC₅₀ of 0.3 nM and demonstrating at least 100–fold selectivity over other sodium channel subtypes. By decreasing channel conductance and shifting activation to more positive potentials, ProTx II TFA effectively inhibits sodium currents and blocks action potential propagation in nociceptors. This makes it a valuable tool in pain research, particularly for studying the role of Nav1.7 in nociceptive signaling and developing targeted analgesic therapies.

Reference

[1]. Tanaka K, et al. Antihyperalgesic effects of ProTx-II, a Nav1.7 antagonist, and A803467, a Nav1.8 antagonist, in diabetic mice. J Exp Pharmacol. 2015 Jun 24;7:11-6.
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[2]. Schmalhofer WA, et al. ProTx-II, a selective inhibitor of NaV1.7 sodium channels, blocks action potential propagation in nociceptors. Mol Pharmacol. 2008 Nov;74(5):1476-84.
[Content Brief]