For research use only. Not for therapeutic Use.
PRRSV/CD163-IN-1 is a PRRSV/CD163 inhibitor. PRRSV/CD163-IN-1 can inhibit the interaction between the PRRSV glycoprotein (GP2a or GP4) and the CD163-SRCR5 domain. PRRSV/CD163-IN-1 can be used for the research of porcine reproductive and respiratory syndrome (PRRS) [1].
PRRSV/CD163-IN-1 (Compound B7) (5 μM) inhibits the Protein-protein interaction (PPI) between PRRSV GP4 glycoprotein and CD163-SRCR5 domain[1].
PRRSV/CD163-IN-1 (24 h) is well-tolerated by PAMs at concentrations below 25 μM, with the LC50 value of 81.7 μM[1].
PRRSV/CD163-IN-1 (0, 5, 10, 15, or 20 μM; 4 h) inhibits PRRSV infection of PAMs in a dose-dependent manner[1].
PRRSV/CD163-IN-1 (15 μM) significantly inhibits the infection caused by both type I and type II PRRSV strains[1].
| Catalog Number | I042494 |
| CAS Number | 560995-89-3 |
| Synonyms | 4-fluoro-2-methyl-N-[3-(3-morpholin-4-ylsulfonylanilino)quinoxalin-2-yl]benzenesulfonamide |
| Molecular Formula | C25H24FN5O5S2 |
| Purity | ≥95% |
| InChI | InChI=1S/C25H24FN5O5S2/c1-17-15-18(26)9-10-23(17)37(32,33)30-25-24(28-21-7-2-3-8-22(21)29-25)27-19-5-4-6-20(16-19)38(34,35)31-11-13-36-14-12-31/h2-10,15-16H,11-14H2,1H3,(H,27,28)(H,29,30) |
| InChIKey | UWRWJHDKWAZXHN-UHFFFAOYSA-N |
| SMILES | CC1=C(C=CC(=C1)F)S(=O)(=O)NC2=NC3=CC=CC=C3N=C2NC4=CC(=CC=C4)S(=O)(=O)N5CCOCC5 |
| Reference | [1]. Chang Huang, et al. Small molecules block the interaction between porcine reproductive and respiratory syndrome virus and CD163 receptor and the infection of pig cells. Virol J. 2020 Jul 30;17(1):116 |
