For research use only. Not for therapeutic Use.
PRT543 is a potent and selective inhibitor of protein arginine methyltransferase 5 (PRMT5) with broad antitumor activity in vitro and in vivo. It also inhibits the methyltransferase activity of the PRMT5/MEP50 complex with an IC50 of 10.8 nM.
| Catalog Number | I047432 |
| CAS Number | 1989620-03-2 |
| Molecular Formula | C17H17ClN4O4 |
| Purity | ≥95% |
| Reference | [1] Bhagwat N, et al. Cancer Res (2020) 80 (16_Supplement): 2915. |
